Chella h biography of abraham
•
Huan Yang
1Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, USA2Department of Immunology, Mayo Clinic, Rochester, Minnesota, USA3Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, St. Paul, Minnesota, USA
Find articles by Huan Yang
Elzbieta Goluszko
1Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, USA2Department of Immunology, Mayo Clinic, Rochester, Minnesota, USA3Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, St. Paul, Minnesota, USA
Find articles by Elzbieta Goluszko
Chella David
1Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, USA2Department of Immunology, Mayo Clinic, Rochester, Minnesota, USA3Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota,
•
Browse research from the School of Engineering, Computing and Mathematics.
Follow
Submissions from 2019
Information security burnout: Identification of sources and mitigating factors from security demands and resources, Pham H Cong, L Brennan, and SM Furnell
“Gravity” - a new simple negative pressure wound therapy self-build design for low income countries, AJ Ramadhar, F Abraham, and C McAllen
Agent-based Vs Agent-less Sandbox for Dynamic Behavioral Analysis, M Ali, S Shiaeles, M Papadaki, and B Ghita
A Framework for Reporting and Dealing with End-User Security Policy Compliance, Mutlaq Jalimid Alotaibi, Steven Furnell, and Nathan Clarke
Would a Robot Trust You? Developmental Robotics Model of Trust and Theory of Mind, A Cangelosi
Uniaxial Damaged Plastic Constitutive Relation of Recycled Aggregate Concrete, Shanshan Cheng, Xiaobin Hu, and Qinwang Lu
Evaluation of tensile properties of fibers extracted from banana peels, Carlo Sant
•
Abstract
Among the exotoxins produced bygd Staphylococcus aureus and Streptococcus pyogenes, the superantigens (SAgs) are the most potent T-cell activators known to date. SAgs are implicated in several serious diseases including toxic shock syndrome (TSS), Kawasaki disease, and sepsis. However, the immunopathogenesis of TSS and other diseases involving SAgs are still not completely understood. The commonly used conventional laboratory mouse strains do not respond robustly to SAgs in vivo. Therefore, they must be artificially rendered susceptible to TSS by using sensitizing agents such as d-galactosamine (d-galN), which skews the disease exclusively to the liver and, hence, is not representative of the disease in humans. SAg-induced TSS was characterized using transgenic mice expressing HLA class II molecules that are extremely susceptible to TSS without d-galN. HLA-DR3 transgenic mice recapitulated TSS in humans with extensive multiple-organ inflammation affecting the lung, liv